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#metabolic health

3 summaries

Three Biomarkers, One Blood Draw: Predicting Heart Attack and Stroke Risk 30 Years Early

A 30-year study of nearly 28,000 women published in The New England Journal of Medicine found that a single blood test measuring hsCRP, LDL cholesterol, and lipoprotein(a) can predict major cardiovascular events decades in advance. Women elevated in all three markers faced 2.6 times the risk of heart attack, stroke, or cardiovascular death — and 3.7 times the risk of stroke specifically. The post explains how atherosclerosis develops, why chronic low-grade inflammation matters, and what each marker reveals about vascular health. It also reviews emerging treatments, from FDA-approved low-dose colchicine to experimental RNA therapies targeting the genetically fixed lipoprotein(a).

Ирина Якутенко🇬🇧🇵🇱🇷🇺🇺🇦

Why Your Metabolism Isn't the Problem: The Science and Psychology of Losing Weight

This deep dive dismantles the myths of "slow metabolism" and magic slimming foods, explaining what actually governs weight gain — calorie arithmetic, muscle mass, genetics of appetite, and an evolutionary brain built for scarcity. It covers the science behind semaglutide (Ozempic), why crash diets can permanently lower your basal metabolic rate, and how the body fights back against a deficit by cutting your activity and cranking up your cravings. The second half turns to psychology: the constant battle between the rational prefrontal cortex and the pleasure-driven limbic system, and why willpower alone reliably loses. Practical takeaways include honest calorie tracking, removing temptation from physical reach, and engineering "controlled external compulsion" — trainers, groups, commitments — so circumstances, not willpower, make your decisions for you.

А поговорить?🇬🇧🇵🇱🇷🇺🇺🇦

Why Your Food Should Energize You, Not Put You to Sleep: A Physician's Guide to Active Longevity

Physician and biophysicist Yakov Marshak explains how the Neolithic shift from oil-rich wild seeds to cooked grains rewired the human food instinct — replacing slow hunger with urgent appetite and turning meals from stimulating into sedating. He outlines a simple pulse test for detecting individual food intolerance, the three pillars of "stimulant nutrition" (digestible protein, fiber, and spices), and the leaky-gut cascade that links poor digestion to chronic inflammation. The conversation also covers the biochemistry of arterial plaque and a pomegranate-and-cocoa combination that reportedly reversed atherosclerosis, plus a candid look at A1 versus A2 milk, homogenization, and gout. The core message: healthy eating is deeply individual, and a proper meal should leave you energized rather than reaching for the sofa.

Алексей Дементьев🇬🇧🇵🇱🇷🇺🇺🇦